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Article

Calcium-sensitive interaction between calmodulin and modified forms of rat brain neurogranin/RC3.

Biochemistry - 20 Jun 2000

Huang K P, Huang F L, Li J, Schuck P, McPhie P

Abstract excerpt

Neurogranin (NG) binding of calmodulin (CaM) at its IQ domain is sensitive to Ca(2+) concentration and to modifications by protein kinase C (PKC) and oxidants. The PKC phosphorylation site of NG is within the IQ domain whereas the four oxidant-sensitive Cys residues are outside this region. These Cys residues were oxidized forming two pairs of intramolecular disulfides, and could also be glutathiolated by...

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Identifiers

PMID: 10852729
DOI: 10.1021/bi000336l

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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