Article
Role of beta isoform-specific insertions of Ca2+/calmodulin-dependent protein kinase II.
European journal of biochemistry - 1 Sept 2001
Urushihara M, Yamauchi T
Abstract excerpt
Alpha and beta isoforms of Ca2+/calmodulin-dependent protein kinase II (alpha and beta CaM kinase II, respectively) are highly conserved except for beta-specific insertions 1 and 2, located at amino acids 316-340 and 354-392, respectively. To investigate the role of these beta-specific insertions, we prepared the deletion mutants betaDelta1, betaDelta2 and betaDelta1/2, which lacked insertions 1, 2 and both,...
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