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Article

Effect of phosphomimetic mutations on the C-terminal sensitivity of glycine transporter GlyT1 to calpain.

Neuroscience research - 1 Jan 2000

Mihalikova Andrea, Baliova Martina, Jursky Frantisek

Abstract excerpt

Previously, we found that the C-terminus of the glycine transporter GlyT1 loses the most of its epitopes during pathological calcium increase in rodent synaptosomes but that the more internal epitopes are spared. We also found that epitope immunoreactivity likely decreases via both phosphorylation and calpain-mediated proteolysis. Here we show that the predicted phosphomimetic mutation S605D fully blocks the...

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Identifiers

PMID: 24566201
DOI: 10.1016/j.neures.2014.02.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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