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Article

Binding and activation of nitric oxide synthase isozymes by calmodulin EF hand pairs.

The FEBS journal - 1 Apr 2006

Spratt Donald E, Newman Elena, Mosher Jennifer, Ghosh Dipak K, Salerno John C, Guillemette J G

Abstract excerpt

Calmodulin (CaM) is a cytosolic Ca(2+) signal-transducing protein that binds and activates many different cellular enzymes with physiological relevance, including the nitric oxide synthase (NOS) isozymes. CaM consists of two globular domains joined by a central linker; each domain contains an EF hand pair. Four different mutant CaM proteins were used to investigate the role of the two CaM EF hand pairs in the...

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Identifiers

PMID: 16623711
DOI: 10.1111/j.1742-4658.2006.05193.x

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