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Article

Neuroprotective effects of calmodulin peptide 76-121aa: disruption of calmodulin binding to mutant huntingtin.

Brain pathology (Zurich, Switzerland) - 1 Jan 2010

Dudek Nichole L, Dai Ying, Muma Nancy A

Abstract excerpt

Huntington's disease (HD) is a neurodegenerative disease caused by mutant huntingtin protein containing an expanded polyglutamine tract, which may cause abnormal protein-protein interactions such as increased association with calmodulin (CaM). We previously demonstrated in HEK293 cells that a pep...

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Identifiers

PMID: 19338577
DOI: 10.1111/j.1750-3639.2008.00258.x
PMCID: PMC2805873

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19338577-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Neuroprotective effects of calmodulin peptide 76-121aa: disruption of calmodulin binding to mutant huntingtin.PMID 19338577Read ↗

Protective effects of interrupting the binding of calmodulin to mutant huntingtin.Semantic proximity Read ↗

Decreased Interactions between Calmodulin and a Mutant Huntingtin Model Might Reduce the Cytotoxic Level of Intracellular Ca2+: A Molecular Dynamics Study.Semantic proximity Read ↗

Expansion of polyglutamine repeat in huntingtin leads to abnormal protein interactions involving calmodulin.Semantic proximity Read ↗

Inhibiting cellular uptake of mutant huntingtin using a monoclonal antibody: Implications for the treatment of Huntington's disease.Semantic proximity Read ↗

Calmodulin mediates the Ca2+-dependent regulation of Cx44 gap junctions.Semantic proximity Read ↗

Spectroscopic characterization of the interaction between calmodulin-dependent protein kinase I and calmodulin.Semantic proximity Read ↗

Therapeutic Advances for Huntington’s DiseaseSemantic proximity Read ↗

Human disease-associated calmodulin mutations alter calcineurin function through multiple mechanisms.Semantic proximity Read ↗

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