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Article

In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate.

Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 2008

Essalmani Rachid, Zaid Ahmed, Marcinkiewicz Jadwiga, Chamberland Ann, Pasquato Antonella, Seidah Nabil G, Prat Annik

Abstract excerpt

The proprotein convertase PC5/6 cleaves protein precursors after basic amino acids and is essential for implantation in CD1/129/Sv/C57BL/6 mixed-background mice. Conditional inactivation of Pcsk5 in the epiblast but not in the extraembryonic tissue bypassed early embryonic lethality but resulted in death at birth. PC5/6-deficient embryos exhibited Gdf11-related phenotypes such as altered anteroposterior...

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Identifiers

PMID: 18378898
DOI: 10.1073/pnas.0709428105
PMCID: PMC2299217

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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