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Article

XPACE4 is a localized pro-protein convertase required for mesoderm induction and the cleavage of specific TGFbeta proteins in Xenopus development.

Development (Cambridge, England) - 1 Feb 2005

Birsoy Bilge, Berg Linnea, Williams P Huw, Smith James C, Wylie Christopher C, Christian Jan L, Heasman Janet

Abstract excerpt

XPACE4 is a member of the subtilisin/kexin family of pro-protein convertases. It cleaves many pro-proteins to release their active proteins, including members of the TGFbeta family of signaling molecules. Studies in mouse suggest it may have important roles in regulating embryonic tissue specification. Here, we examine the role of XPACE4 in Xenopus development and make three novel observations: first, XPACE4 is...

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Identifiers

PMID: 15634697
DOI: 10.1242/dev.01599

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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