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Article

XPACE4 is a localized pro-protein convertase required for mesoderm induction and the cleavage of specific TGFbeta proteins in Xenopus development.

Development (Cambridge, England) - 1 Feb 2005

Birsoy Bilge, Berg Linnea, Williams P Huw, Smith James C, Wylie Christopher C, Christian Jan L, Heasman Janet

Abstract excerpt

XPACE4 is a member of the subtilisin/kexin family of pro-protein convertases. It cleaves many pro-proteins to release their active proteins, including members of the TGFbeta family of signaling molecules. Studies in mouse suggest it may have important roles in regulating embryonic tissue specific...

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Identifiers

PMID: 15634697
DOI: 10.1242/dev.01599

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15634697-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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