Article
The role of chordin/Bmp signals in mammalian pharyngeal development and DiGeorge syndrome.
Development (Cambridge, England) - 1 Aug 2003
Bachiller Daniel, Klingensmith John, Shneyder Natalya, Tran Uyen, Anderson Ryan, Rossant Janet, De Robertis E M
Abstract excerpt
The chordin/Bmp system provides one of the best examples of extracellular signaling regulation in animal development. We present the phenotype produced by the targeted inactivation of the chordin gene in mouse. Chordin homozygous mutant mice show, at low penetrance, early lethality and a ventralized gastrulation phenotype. The mutant embryos that survive die perinatally, displaying an extensive array of...
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