Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pcsk5 is required in the early cranio-cardiac mesoderm for heart development.

BMC developmental biology - 26 Apr 2017

Szumska Dorota, Cioroch Milena, Keeling Angela, Prat Annik, Seidah Nabil G, Bhattacharya Shoumo

Abstract excerpt

BACKGROUND: Loss of proprotein convertase subtilisin/kexin type 5 (Pcsk5) results in multiple developmental anomalies including cardiac malformations, caudal regression, pre-sacral mass, renal agenesis, anteroposterior patterning defects, and tracheo-oesophageal and anorectal malformations, and is a model for VACTERL/caudal regression/Currarino syndromes (VACTERL association - Vertebral anomalies, Anal atresia,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Knockout Techniques
Share to Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mesoderm

Share to Mice, Knockout

Share to Mutation

Share to Organogenesis

Source

Open in PubMed Open full text

Identifiers

PMID: 28446132
DOI: 10.1186/s12861-017-0148-y
PMCID: PMC5407003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pcsk5 is required in the early cranio-cardiac mesoderm for heart development.PMID 28446132Read ↗

Genetics of Congenital Heart Defects: The NKX2-5 Gene, a Key PlayerSemantic proximity Read ↗

Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3.Semantic proximity Read ↗

Nkx2-5 and Sarcospan genetically interact in the development of the muscular ventricular septum of the heart.Semantic proximity Read ↗

The role of chordin/Bmp signals in mammalian pharyngeal development and DiGeorge syndrome.Semantic proximity Read ↗

The Cardiac Neural Crest Cells in Heart Development and Congenital Heart DefectsSemantic proximity Read ↗

An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation.Semantic proximity Read ↗

Essential Role for ADAM19 in Cardiovascular MorphogenesisSemantic proximity Read ↗

BMP signaling in congenital heart disease: New developments and future directionsSemantic proximity Read ↗

In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate.Semantic proximity Read ↗

Furin, a transcriptional target of NKX2-5, has an essential role in heart development and function.Semantic proximity Read ↗

Ablation of Nkx2-5 at mid-embryonic stage results in premature lethality and cardiac malformationSemantic proximity Read ↗

Defective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defectsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.