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Article

Multiple joint and skeletal patterning defects caused by single and double mutations in the mouse Gdf6 and Gdf5 genes.

Developmental biology - 1 Feb 2003

Settle Stephen H, Rountree Ryan B, Sinha Abhishek, Thacker Abigail, Higgins Kay, Kingsley David M

Abstract excerpt

Growth/differentiation factors 5, 6, and 7 (GDF5/6/7) represent a distinct subgroup within the bone morphogenetic protein (BMP) family of secreted signaling molecules. Previous studies have shown that the Gdf5 gene is expressed in transverse stripes across developing skeletal elements and is one of the earliest known markers of joint formation during embryonic development. Although null mutations in this gene...

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PMID: 12606286
DOI: 10.1016/s0012-1606(02)00022-2

Genes

GDF5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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