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Article

Disruption of Ledgf/Psip1 results in perinatal mortality and homeotic skeletal transformations.

Molecular and cellular biology - 1 Oct 2006

Sutherland Heidi G, Newton Kathryn, Brownstein David G, Holmes Megan C, Kress Clémence, Semple Colin A, Bickmore Wendy A

Abstract excerpt

PC4- and SF2-interacting protein 1 (Psip1)-also known as lens epithelium-derived growth factor (Ledgf)-is a chromatin-associated protein that has been implicated in transcriptional regulation, mRNA splicing, and cell survival in vitro, but its biological function in vivo is unknown. We identified an embryonic stem cell clone with disrupted Psip1 in a gene trap screen. The resulting Psip1-betageo fusion protein...

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Source

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Identifiers

PMID: 16980622
DOI: 10.1128/MCB.00459-06
PMCID: PMC1592893

Genes

NUP98
PSIP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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