Requirement of the C-terminal region of adenovirus E1a for cell transformation in cooperation with E1b.

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Article

Requirement of the C-terminal region of adenovirus E1a for cell transformation in cooperation with E1b.

Oncogene - 1 Jul 1991

Subramanian T, Malstrom S E, Chinnadurai G

Abstract excerpt

We have previously reported that adenovirus E1a mutants lacking the C-terminal 61 or 67 amino acids were severely defective in immortalization, but cooperated more efficiently (than wt E1a) with activated T24 ras oncogene in transformation of primary rat kidney (BRK) cells (Subramanian et al., 19...

Topics

Adenoviridae
Adenovirus Early Proteins
Amino Acid Sequence
Animals
Cell Line
Cell Transformation, Neoplastic
Cell Transformation, Viral
DNA, Viral
DNA-Binding Proteins
Kidney
Molecular Sequence Data
Mutation
Oncogene Proteins, Viral
Rats

Source

Open in PubMed

Identifiers

PMID: 1830644

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1830644-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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