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Article

Requirement of the C-terminal region of adenovirus E1a for cell transformation in cooperation with E1b.

Oncogene - 1 Jul 1991

Subramanian T, Malstrom S E, Chinnadurai G

Abstract excerpt

We have previously reported that adenovirus E1a mutants lacking the C-terminal 61 or 67 amino acids were severely defective in immortalization, but cooperated more efficiently (than wt E1a) with activated T24 ras oncogene in transformation of primary rat kidney (BRK) cells (Subramanian et al., 1989; Oncogene, 4:415-420). Here, we show that in contrast to these previous results, transformation of BRK cells in...

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PMID: 1830644

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