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Article

The Ino80 chromatin-remodeling enzyme regulates replisome function and stability.

Nature structural & molecular biology - 1 Apr 2008

Papamichos-Chronakis Manolis, Peterson Craig L

Abstract excerpt

Previous studies have demonstrated essential roles for ATP-dependent chromatin-remodeling and chromatin-modifying enzymes in gene transcription and DNA repair, but few studies have addressed how the replication machinery deals with chromatin. Here we show that the Ino80 remodeling enzyme is recruited to replication origins as cells enter S phase. Inducible degradation of Ino80 shows that it is required...

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Identifiers

PMID: 18376411
DOI: 10.1038/nsmb.1413

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Ino80 chromatin-remodeling enzyme regulates replisome function and stability.PMID 18376411Read ↗

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Advances in understanding DNA processing and protection at stalled replication forksSemantic proximity Read ↗

INO80 and gamma-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair.Semantic proximity Read ↗

The mINO80 chromatin remodeling complex is required for efficient telomere replication and maintenance of genome stability.Semantic proximity Read ↗

BAP1 promotes stalled fork restart and cell survival via INO80 in response to replication stressSemantic proximity Read ↗

A chromatin remodelling complex involved in transcription and DNA processing.Semantic proximity Read ↗

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