Article
Effects of simvastatin on cerebrospinal fluid biomarkers and cognition in middle-aged adults at risk for Alzheimer's disease.
Journal of Alzheimer's disease : JAD - 1 Mar 2008
Carlsson Cynthia M, Gleason Carey E, Hess Timothy M, Moreland Kimberly A, Blazel Hanna M, Koscik Rebecca L, Schreiber Nathan T N, Johnson Sterling C, Atwood Craig S, Puglielli Luigi, Hermann Bruce P, McBride Patrick E, Stein James H, Sager Mark A, Asthana Sanjay
Abstract excerpt
BACKGROUND: Statins reduce amyloid-beta (Abeta) levels in the brain and cerebrospinal fluid (CSF) in animals and may thereby favorably alter the pathobiology of AD. It is unclear if statins modify Abeta metabolism or improve cognition in asymptomatic middle-aged adults at increased risk for AD. METHODS: In a 4-month randomized, double-blind, controlled study, we evaluated the effects of simvastatin 40 mg daily...
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