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Article

The conflicting role of brain cholesterol in Alzheimer's disease: lessons from the brain plasminogen system.

Biochemical Society symposium - 1 Jan 2005

Ledesma Maria Dolores, Dotti Carlos G

Abstract excerpt

Retrospective clinical studies indicate that individuals chronically treated with cholesterol synthesis inhibitors, statins, are at lower risk of developing AD (Alzheimer's disease). Moreover, treatment of guinea pigs with high doses of simvastatin or drastic reduction of cholesterol in cultured cells decrease Abeta (beta-amyloid peptide) production. These data sustain the concept that high brain cholesterol is...

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Identifiers

PMID: 15649137
DOI: 10.1042/bss0720129

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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