Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential effects of simvastatin and pravastatin on expression of Alzheimer's disease-related genes in human astrocytes and neuronal cells

22 May 2009

Abstract excerpt

Inhibitors of HMG-CoA reductase (statins) are widely used medications for reduction of cholesterol levels. Statin use significantly reduces risk of cardiovascular disease but has also been associated with lower risk of other diseases and conditions, including dementia. However, some reports suggest that statins also have detrimental effects on the brain. We provide evidence that simvastatin and pravastatin have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Computational Drug Discovery Methods
Share to Lipoproteins and Cardiovascular Health
Share to Nuclear Receptors and Signaling

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19461118
DOI: 10.1194/jlr.m900236-jlr200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential effects of simvastatin and pravastatin on expression of Alzheimer's disease-related genes in human astrocytes and neuronal cellsPMID 19461118Read ↗

Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo.Semantic proximity Read ↗

Nurr1 modulation mediates neuroprotective effects of statinsSemantic proximity Read ↗

Disruption of astrocyte-neuron cholesterol cross talk affects neuronal function in Huntington's disease.Semantic proximity Read ↗

Fluvastatin and lovastatin but not pravastatin induce neuroglial differentiation in human mesenchymal stem cells.Semantic proximity Read ↗

The role of statins as therapeutic agents in cancerSemantic proximity Read ↗

Statins suppress cell-to-cell propagation of α-synuclein by lowering cholesterolSemantic proximity Read ↗

Acetylsalicylic Acid Suppresses Alcoholism-Induced Cognitive Impairment Associated with Atorvastatin Intake by Targeting Cerebral miRNA155 and NLRP3: In Vivo, and In Silico StudySemantic proximity Read ↗

Chronic Administration of Statins Alters Multiple Gene Expression Patterns in Mouse Cerebral CortexSemantic proximity Read ↗

Effects of simvastatin on cerebrospinal fluid biomarkers and cognition in middle-aged adults at risk for Alzheimer's disease.Semantic proximity Read ↗

Induction of fibroblast apolipoprotein E expression during apoptosis, starvation-induced growth arrest and mitosisSemantic proximity Read ↗

Investigating the impact of anaesthesia and surgery on Alzheimer's disease and the potential therapeutic role of StatinSemantic proximity Read ↗

Histone deacetylase inhibition decreases cholesterol levels in neuronal cells by modulating key genes in cholesterol synthesis, uptake and efflux.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.