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Article

Apolipoprotein E, cholesterol transport and synthesis in sporadic Alzheimer's disease.

Neurobiology of aging - 1 Mar 2005

Poirier Judes

Abstract excerpt

The discovery that the apolipoprotein E4 (apoE4) allele is genetically linked to both sporadic and familial late onset Alzheimer's disease (AD) raises the possibility that a dysfunction of the lipid transport system could seriously affect lipid homeostasis in the brain of AD subjects. The presence of the E4 allele has been associated with lower levels of apoE in both serum and brain tissues of normal and AD...

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Identifiers

PMID: 15639314
DOI: 10.1016/j.neurobiolaging.2004.09.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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