Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Statins have therapeutic potential for the treatment of Alzheimer's disease, likely via protection of the neurovascular unit in the AD brain.

Journal of the neurological sciences - 15 Nov 2012

Kurata Tomoko, Kawai Hiromi, Miyazaki Kazunori, Kozuki Miki, Morimoto Nobutoshi, Ohta Yasuyuki, Ikeda Yoshio, Abe Koji

Abstract excerpt

Structural and functional abnormalities in the neurovascular unit (NVU) have been recently observed in Alzheimer's disease (AD). Statins, which are used clinically for reducing cholesterol levels, can also exert beneficial vascular actions, improve behavioral memory and reduce senile plaque (SP). Thus, we examined cognitive function, the serum level of lipids, senile plaque (SP), and the protective effects of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anticholesteremic Agents
Share to Atorvastatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Collagen Type IV

Share to Glial Fibrillary Acidic Protein

Share to Glucosamine

Share to Heptanoic Acids

Share to Pyrroles

Share to Quinolines

Source

Identifiers

PMID: 22795384
DOI: 10.1016/j.jns.2012.06.011

Genes

APP
GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Statins have therapeutic potential for the treatment of Alzheimer's disease, likely via protection of the neurovascular unit in the AD brain.PMID 22795384Read ↗

The Role of Statins in the Prevention and Management of Alzheimer’s Disease: A Focused ReviewSemantic proximity Read ↗

[The role of cholesterol in Alzheimer's neuro-pathogenesis].Semantic proximity Read ↗

Selective benefits of simvastatin in bitransgenic APPSwe,Ind/TGF-β1 mice.Semantic proximity Read ↗

Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo.Semantic proximity Read ↗

Effects of simvastatin on cerebrospinal fluid biomarkers and cognition in middle-aged adults at risk for Alzheimer's disease.Semantic proximity Read ↗

Multiple substrates of late-onset dementia: implications for brain protection.Semantic proximity Read ↗

Cerebral small vessel disease and Alzheimer's disease.Semantic proximity Read ↗

Interplay Between Vascular Dysfunction and Neurodegenerative Pathology: New Insights into Molecular Mechanisms and ManagementSemantic proximity Read ↗

Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease modelSemantic proximity Read ↗

Cerebrovascular phenotypes in mouse models of Alzheimer's disease.Semantic proximity Read ↗

Vascular factors and prevention of dementia.Semantic proximity Read ↗

Vascular smooth muscle cell dysfunction contribute to neuroinflammation and Tau hyperphosphorylation in Alzheimer diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.