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Article

Long-term statin therapy and CSF cholesterol levels: implications for Alzheimer's disease.

Dementia and geriatric cognitive disorders - 1 Jan 2009

Evans Barbara A, Evans James E, Baker Stephen P, Kane Kevin, Swearer Joan, Hinerfeld Douglas, Caselli Richard, Rogaeva Ekaterina, St George-Hyslop Peter, Moonis Majaz, Pollen Daniel A

Abstract excerpt

BACKGROUND/AIMS: It is not yet established whether statins (lipophilic or hydrophilic) reduce the risk of Alzheimer's disease and, if so, by differentially modifying brain lipid levels. Our aim was to assess changes in brain cholesterol metabolism as reflected in the cerebrospinal fluid (CSF) before and after treatment with either atorvastatin or simvastatin. METHODS: We carried out a longitudinal analysis of CSF...

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Identifiers

PMID: 19478483
DOI: 10.1159/000221835

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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