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Article

Cross-sectional assessment of the consequences of a GTP cyclohydrolase 1 haplotype for specialized tertiary outpatient pain care.

The Clinical journal of pain - 1 Jan 2000

Doehring Alexandra, Freynhagen Rainer, Griessinger Norbert, Zimmermann Michael, Sittl Reinhard, Hentig Nils von, Geisslinger Gerd, Lötsch Jörn

Abstract excerpt

OBJECTIVES: Reduced-function variants of the guanosine triphosphate cyclohydrolase gene (GCH1) have been associated with reduced pain in well-defined cohorts of patients and healthy volunteers. We addressed the question whether this genetic association plays a role in outpatient pain therapy. METHODS: In a cross-sectional observational study, 523 patients were enrolled in 3 different tertiary care outpatient pain...

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Source

Identifiers

PMID: 19851158
DOI: 10.1097/AJP.0b013e3181b43e12

Genes

GCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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