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Article

Do genetic predictors of pain sensitivity associate with persistent widespread pain?

Molecular pain - 23 Sept 2009

Holliday Kate L, Nicholl Barbara I, Macfarlane Gary J, Thomson Wendy, Davies Kelly A, McBeth John

Abstract excerpt

Genetic risk factors for pain sensitivity may also play a role in susceptibility to chronic pain disorders, in which subjects have low pain thresholds. The aim of this study was to determine if proposed functional single nucleotide polymorphisms (SNPs) in the GTP cyclohydrolase (GCH1) and mu opioid receptor (OPRM1) genes previously associated with pain sensitivity affect susceptibility to chronic widespread pain...

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Source

Open in PubMed Open full text

Identifiers

PMID: 19775452
DOI: 10.1186/1744-8069-5-56
PMCID: PMC2759922

Genes

OPRM1
GCH1
CAT

Variants

rs10483639

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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