Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of guanosine triphosphate cyclohydrolase 1 gene polymorphisms with fibromyalgia syndrome in a Korean population.

The Journal of rheumatology - 1 Mar 2013

Kim Seong-Kyu, Kim Seong-Ho, Nah Seong-Su, Lee Ji Hyun, Hong Seung-Jae, Kim Hyun-Sook, Lee Hye-Soon, Kim Hyoun Ah, Joung Chung-Il, Bae Jisuk, Choe Jung-Yoon, Lee Shin-Seok

Abstract excerpt

OBJECTIVE: Guanosine triphosphate cyclohydrolase 1 (GCH1) is the rate-limiting enzyme in the synthesis of tetrahydrobiopterin, which is an essential cofactor in nitric oxide (NO) production. Polymorphisms in the GCH1 gene have been implicated in protection against pain sensitivity. The aim of our study was to determine whether single-nucleotide polymorphisms (SNP) in the GCH1 gene affect susceptibility and/or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Asian People

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibromyalgia

Share to Genetic Association Studies

Share to GTP Cyclohydrolase

Share to Haplotypes

Share to Pain Threshold

Share to Republic of Korea

Source

Identifiers

PMID: 23322459
DOI: 10.3899/jrheum.120929

Genes

GCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of guanosine triphosphate cyclohydrolase 1 gene polymorphisms with fibromyalgia syndrome in a Korean population.PMID 23322459Read ↗

Fibromyalgia: A Review of Related Polymorphisms and Clinical RelevanceSemantic proximity Read ↗

Identification of candidate genes associated with fibromyalgia susceptibility in southern Spanish women: the al-Ándalus project.Semantic proximity Read ↗

Association between catechol-O-methyl transferase gene polymorphisms and fibromyalgia in a Korean population: A case-control study.Semantic proximity Read ↗

Heritability of the Fibromyalgia Phenotype Varies by Age.Semantic proximity Read ↗

Genome-wide analysis of single nucleotide polymorphisms and copy number variants in fibromyalgia suggest a role for the central nervous system.Semantic proximity Read ↗

Clinical genetics of functionally mild non-coding GTP cyclohydrolase 1 (GCH1) polymorphisms modulating pain and cardiovascular risk.Semantic proximity Read ↗

A Comprehensive Review of the Genetic and Epigenetic Contributions to the Development of FibromyalgiaSemantic proximity Read ↗

Gene-to-gene interactions regulate endogenous pain modulation in fibromyalgia patients and healthy controls-antagonistic effects between opioid and serotonin-related genes.Semantic proximity Read ↗

New insights into the genetics of fibromyalgia.Semantic proximity Read ↗

Reliable screening for a pain-protective haplotype in the GTP cyclohydrolase 1 gene (GCH1) through the use of 3 or fewer single nucleotide polymorphisms.Semantic proximity Read ↗

Influence of Oxidative Stress-Related Genes on Susceptibility to Fibromyalgia.Semantic proximity Read ↗

Pain sensitivity in fibromyalgia is associated with catechol-O-methyltransferase (COMT) gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.