Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Does the pain-protective GTP cyclohydrolase haplotype significantly alter the pattern or severity of pain in humans with chronic pancreatitis?

Molecular pain - 17 Nov 2008

Lazarev Mark, Lamb Janette, Barmada M Michael, Dai Feng, Anderson Michelle A, Max Mitchell B, Whitcomb David C

Abstract excerpt

BACKGROUND: Pain is often a dominant clinical feature of chronic pancreatitis but the frequency and severity is highly variable between subjects. We hypothesized that genetic polymorphisms contribute to variations in clinical pain patterns. Since genetic variations in the GTP cyclohydrolase (GCH1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Cohort Studies
Share to GTP Cyclohydrolase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Haplotypes

Share to Pain Threshold

Share to Pancreatitis, Chronic

Share to Sensitivity and Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 19014702
DOI: 10.1186/1744-8069-4-58
PMCID: PMC2626574

Genes

GCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19014702-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Does the pain-protective GTP cyclohydrolase haplotype significantly alter the pattern or severity of pain in humans with chronic pancreatitis?PMID 19014702Read ↗

Beyond Ammann's pain classification: multidimensional pain phenotyping and cluster analysis in chronic pancreatitis.Semantic proximity Read ↗

Individualized Pain Treatment in Chronic Pancreatitis (INPAIN): An International, Multicenter, Investigator-Initiated, Prospective, Cohort Study.Semantic proximity Read ↗

Do genetic predictors of pain sensitivity associate with persistent widespread pain?Semantic proximity Read ↗

Reliable screening for a pain-protective haplotype in the GTP cyclohydrolase 1 gene (GCH1) through the use of 3 or fewer single nucleotide polymorphisms.Semantic proximity Read ↗

Characterizing mechanism-based pain phenotypes in patients with chronic pancreatitis: a cross-sectional analysis of the PROspective Evaluation of Chronic Pancreatitis for EpidEmiologic and Translational StuDies.Semantic proximity Read ↗

Pain Experience in Pancreatitis: Strong Association of Genetic Risk Loci for Anxiety and PTSD in Patients With Severe, Constant, and Constant-Severe Pain.Semantic proximity Read ↗

Polymorphisms in the GTP cyclohydrolase gene ( GCH1 ) are associated with ratings of capsaicin painSemantic proximity Read ↗

A Self-Reported Electronic Body Map Identifies Distinct Clinical Pain Phenotypes in Chronic Pancreatitis.Semantic proximity Read ↗

Cross-sectional assessment of the consequences of a GTP cyclohydrolase 1 haplotype for specialized tertiary outpatient pain care.Semantic proximity Read ↗

Reduced hyperalgesia in homozygous carriers of a GTP cyclohydrolase 1 haplotype.Semantic proximity Read ↗

Pancreatic QST Differentiates Chronic Pancreatitis Patients into Distinct Pain Phenotypes Independent of Psychiatric Comorbidities.Semantic proximity Read ↗

Lack of influence of GTP cyclohydrolase gene (GCH1) variations on pain sensitivity in humans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.