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Article

A GTP cyclohydrolase 1 genetic variant delays cancer pain.

Pain - 1 Jan 2010

Lötsch Jörn, Klepstad Pål, Doehring Alexandra, Dale Ola

Abstract excerpt

Pain is a major symptom in 70% of patients with advanced cancer. We analyzed data of 251 cancer patients (142 men and 109 women aged 29-89 years, Karnofsky status 10-90, 65.7+/-13.9) for association of a reduced-function haplotype in the GTP cyclohydrolase 1 (GCH1) gene with cancer pain therapy. The interval between cancer diagnosis and opioid therapy initiation was significantly (p=0.002) longer in homozygous...

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Source

Identifiers

PMID: 19959292
DOI: 10.1016/j.pain.2009.10.021

Genes

GCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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