Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reliable screening for a pain-protective haplotype in the GTP cyclohydrolase 1 gene (GCH1) through the use of 3 or fewer single nucleotide polymorphisms.

Clinical chemistry - 1 Jun 2007

Lötsch Jörn, Belfer Inna, Kirchhof Anja, Mishra Bikash K, Max Mitchell B, Doehring Alexandra, Costigan Michael, Woolf Clifford J, Geisslinger Gerd, Tegeder Irmgard

Abstract excerpt

BACKGROUND: A haplotype in the GTP cyclohydrolase 1 (dopa-responsive dystonia) gene (GCH1) is associated with decreased persistent pain. The aim of the present study was to develop a screening method for the pain-protective haplotype. METHODS: Complete genetic information for all 15 GCH1 DNA positions constituting the pain-protective GCH1 haplotype was available from 278 patients. In silico analyses, including...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to GTP Cyclohydrolase
Share to Haplotypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heterozygote

Share to Homozygote

Share to Molecular Diagnostic Techniques

Share to Reproducibility of Results

Share to Sensitivity and Specificity

Source

Identifiers

PMID: 17363416
DOI: 10.1373/clinchem.2006.082883

Genes

GCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reliable screening for a pain-protective haplotype in the GTP cyclohydrolase 1 gene (GCH1) through the use of 3 or fewer single nucleotide polymorphisms.PMID 17363416Read ↗

Clinical genetics of functionally mild non-coding GTP cyclohydrolase 1 (GCH1) polymorphisms modulating pain and cardiovascular risk.Semantic proximity Read ↗

Heterozygous mutations in GTP-cyclohydrolase-1 reduce BH4 biosynthesis but not pain sensitivity.Semantic proximity Read ↗

Parkinson's disease in GTP cyclohydrolase 1 mutation carriers.Semantic proximity Read ↗

Cross-sectional assessment of the consequences of a GTP cyclohydrolase 1 haplotype for specialized tertiary outpatient pain care.Semantic proximity Read ↗

Do genetic predictors of pain sensitivity associate with persistent widespread pain?Semantic proximity Read ↗

GCH1 mutations are common in Serbian patients with dystonia-parkinsonism: Challenging previously reported prevalence rates of DOPA-responsive dystonia.Semantic proximity Read ↗

Polymorphisms in the GTP cyclohydrolase gene ( GCH1 ) are associated with ratings of capsaicin painSemantic proximity Read ↗

Association of guanosine triphosphate cyclohydrolase 1 gene polymorphisms with fibromyalgia syndrome in a Korean population.Semantic proximity Read ↗

Pathogenic Variant in the 5'-Untranslated Region of GCH1 and Clinical Heterogeneity in a Chinese Family with Dopa-Responsive Dystonia.Semantic proximity Read ↗

Dopa-Responsive Dystonia in Han Chinese Patients: One Novel Heterozygous Mutation in GTP Cyclohydrolase 1 (GCH1) and Three Known Mutations in TH.Semantic proximity Read ↗

Novel GCH1 variant in Dopa-responsive dystonia and Parkinson's disease.Semantic proximity Read ↗

GCH1 mutations in hereditary spastic paraplegia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.