Article
Quantification of the genetic component of basal C-reactive protein expression in SLE nuclear families.
Annals of human genetics - 1 Sept 2008
Rhodes B, Meek J, Whittaker J C, Vyse T J
Abstract excerpt
C-reactive protein (CRP) is a heritable acute-phase plasma protein also expressed at low, basal, levels in healthy individuals. Elevated basal CRP has been associated with increased cardiovascular risk, while CRP dysregulation may be a feature of systemic lupus erythematosus (SLE). In this cohort of 496 Caucasian SLE families we estimated basal CRP heritability, h(2)= 27.7%. We typed a dense map of CRP single...
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