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Article

Polymorphism at the C-reactive protein locus influences gene expression and predisposes to systemic lupus erythematosus.

Human molecular genetics - 1 Jan 2004

Russell Andrew I, Cunninghame Graham Deborah S, Shepherd Christopher, Roberton Cheri A, Whittaker John, Meeks John, Powell Richard J, Isenberg David A, Walport Mark J, Vyse Timothy J

Abstract excerpt

Relative deficiency of pentraxin proteins is implicated in the pathogenesis of systemic lupus erythematosus. The C-reactive protein (CRP) response is defective in patients with acute flares of disease, and mice with targeted deletions of the serum amyloid P component gene (Sap) develop a lupus-like illness. In humans, the genes for CRP (CRP) and SAP (APCS) map to 1q23.2 within an interval linked with SLE. We have...

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Identifiers

PMID: 14645206
DOI: 10.1093/hmg/ddh021
PMCID: PMC3707088

Genes

CRP
APCS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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