Article
Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels.
American journal of human genetics - 1 Jul 2005
Carlson Christopher S, Aldred Shelley Force, Lee Philip K, Tracy Russell P, Schwartz Stephen M, Rieder Mark, Liu Kiang, Williams O Dale, Iribarren Carlos, Lewis E Cora, Fornage Myriam, Boerwinkle Eric, Gross Myron, Jaquish Cashell, Nickerson Deborah A, Myers Richard M, Siscovick David S, Reiner Alexander P
Abstract excerpt
Elevated plasma levels of C-reactive protein (CRP), an inflammation-sensitive marker, have emerged as an important predictor of future cardiovascular disease and metabolic abnormalities in apparently healthy men and women. Here, we performed a systematic survey of common nucleotide variation across the genomic region encompassing the CRP gene locus. Of the common single-nucleotide polymorphisms (SNPs) identified,...
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