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Article

Substantial regional variation in substitution rates in the human genome: importance of GC content, gene density, and telomere-specific effects.

Journal of molecular evolution - 1 Jun 2005

Arndt Peter F, Hwa Terence, Petrov Dmitri A

Abstract excerpt

This study presents the first global, 1-Mbp-level analysis of patterns of nucleotide substitutions along the human lineage. The study is based on the analysis of a large amount of repetitive elements deposited into the human genome since the mammalian radiation, yielding a number of results that would have been difficult to obtain using the more conventional comparative method of analysis. This analysis revealed...

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Identifiers

PMID: 15959677
DOI: 10.1007/s00239-004-0222-5

Genes

GC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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