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Article

NOD2/CARD15 mutations correlate with severe pouchitis after ileal pouch-anal anastomosis.

Diseases of the colon and rectum - 1 Nov 2010

Sehgal Rishabh, Berg Arthur, Hegarty John P, Kelly Ashley A, Lin Zhenwu, Poritz Lisa S, Koltun Walter A

Abstract excerpt

PURPOSE: Pouchitis and Crohn's-like complications can plague patients after IPAA. NOD2 is an intracellular sensor for bacterial cell wall peptidoglycan. NOD2 mutations compromise host response to enteric bacteria and are increased in Crohn's disease. We hypothesize that IPAA patients with complic...

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Source

Identifiers

PMID: 20940596
DOI: 10.1007/DCR.0b013e3181f22635

Genes

NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20940596-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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