Article
Association of NOD2 (CARD 15) genotype with clinical course of Crohn's disease: a cohort study.
Lancet (London, England) - 11 May 2002
Hampe Jochen, Grebe Jochen, Nikolaus Susanna, Solberg Camilla, Croucher Peter J P, Mascheretti Silvia, Jahnsen Jörgen, Moum Björn, Klump Bodo, Krawczak Michael, Mirza Muddassar M, Foelsch Ulrich R, Vatn Morten, Schreiber Stefan
Abstract excerpt
BACKGROUND: Crohn's disease is a heterogeneous disorder for which NOD2 (CARD 15) has been identified as a susceptibility gene. We investigate the relation between NOD2 genotype and phenotypic characteristics of patients with Crohn's disease. METHODS: Hypotheses about the relation between NOD2 genotype and Crohn's disease phenotype were generated retrospectively from a group of 446 German patients with this...
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