Article
A UVB fingerprint mutation on the p53 tumor suppressor gene decreases in vitro.
Cells, tissues, organs - 1 Jan 2008
Zhang Zhiyuan, Burger Katharina, Hellwig Sven, Bergemann Jörg
Abstract excerpt
The culture of tissue-derived human cells is an important aspect of tissue engineering. Prior to transplantation, the quality of the cultured cells/tissue should be routinely tested so that any enrichment of procarcinogenic cells can be excluded. On this account, a UVB-induced p53 fingerprint mutation would be a valuable quality control marker for skin cells cultured for use in tissue engineering. We developed an...
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