Article
C-->T transition mutations are not solely UVB-signature mutations, because they are also generated by UVA.
The Journal of investigative dermatology - 1 Sept 2008
Rünger Thomas M
Abstract excerpt
In this issue, Ikehata et al. confirm data from cell culture models by showing that the C-->T transition mutation is also the most common UVA-generated mutation in vivo. This indicates that DNA photoproducts are the most important premutagenic lesions not only in UVB mutagenesis, but also in UVA mutagenesis. C-->T transitions cannot therefore be considered solely UVB-signature mutations. In addition, there is no...
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