Article
The mutagenic effect of ultraviolet-A1 on human skin demonstrated by sequencing the p53 gene in single keratinocytes.
Photodermatology, photoimmunology & photomedicine - 1 Dec 2002
Persson Asa E, Edström Desiree W, Bäckvall Helena, Lundeberg Joakim, Pontén Fredrik, Ros Anne-Marie, Williams Cecilia
Abstract excerpt
BACKGROUND: Sun exposure is accepted as the major risk factor for developing skin cancer, the most common cancer in the western world. Ultraviolet-B (UV-B) radiation is considered the causative agent, but recently several findings suggest a role also for ultraviolet-A (UV-A) radiation. Repeated suberythemal doses of ultraviolet-A1 (UV-A1) on healthy human skin induce an increase of p53 immunoreactive cells in...
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