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Article

Herpes simplex virus virion host shutoff attenuates establishment of the antiviral state.

Journal of virology - 1 Jun 2008

Pasieka Tracy Jo, Lu Betty, Crosby Seth D, Wylie Kristine M, Morrison Lynda A, Alexander Diane E, Menachery Vineet D, Leib David A

Abstract excerpt

Herpes simplex virus mutants lacking the vhs protein are severely attenuated in animal models of pathogenesis and exhibit reduced growth in primary cell culture. As a result of these properties, viruses with vhs deleted have been proposed as live-attenuated vaccines. Despite these findings and their implications for vaccines, the mechanisms by which vhs promotes infection in cell culture and in vivo are not...

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Identifiers

PMID: 18367525
DOI: 10.1128/JVI.02047-07
PMCID: PMC2395185

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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