Article
The virion host shut-off (vhs) protein blocks a TLR-independent pathway of herpes simplex virus type 1 recognition in human and mouse dendritic cells.
PloS one - 18 Feb 2010
Cotter Christopher R, Nguyen Marie L, Yount Jacob S, López Carolina B, Blaho John A, Moran Thomas M
Abstract excerpt
Molecular pathways underlying the activation of dendritic cells (DCs) in response to Herpes Simplex Virus type 1 (HSV-1) are poorly understood. Removal of the HSV virion host shut-off (vhs) protein relieves a block to DC activation observed during wild-type infection. In this study, we utilized a potent DC stimulatory HSV-1 recombinant virus lacking vhs as a tool to investigate the mechanisms involved in the...
Topics
- Animals
- Cells, Cultured
- Chlorocebus aethiops
- Cytokines
- Dendritic Cells
- Enzyme-Linked Immunosorbent Assay
- Gene Expression
- Herpesvirus 1, Human
- Host-Pathogen Interactions
- Humans
- Mice
- Mice, Inbred C57BL
- Mice, Knockout