Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Herpes simplex virus type 2 virion host shutoff protein regulates alpha/beta interferon but not adaptive immune responses during primary infection in vivo.

Journal of virology - 1 Sept 2003

Murphy Jenny A, Duerst Rebecca J, Smith Tracy J, Morrison Lynda A

Abstract excerpt

The herpes simplex virus (HSV) virion host shutoff (vhs) protein, the product of the UL41 (vhs) gene, is an important determinant of HSV virulence. vhs has been implicated in HSV interference with host antiviral immune responses, down-regulating expression of major histocompatibility complex molecules to help HSV evade host adaptive immunity. The severe attenuation of vhs-deficient viruses in vivo could reflect...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Herpes Genitalis
Share to Herpesvirus 2, Human

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Interferon-alpha

Share to Interferon-beta

Share to Mice, Congenic

Share to Mice, SCID

Share to Receptor, Interferon alpha-beta

Share to Receptors, Interferon

Source

Open in PubMed Open full text

Identifiers

PMID: 12915549
DOI: 10.1128/jvi.77.17.9337-9345.2003
PMCID: PMC187414

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Herpes simplex virus type 2 virion host shutoff protein regulates alpha/beta interferon but not adaptive immune responses during primary infection in vivo.PMID 12915549Read ↗

Herpes simplex virus 2 virion host shutoff protein interferes with type I interferon production and responsiveness.Semantic proximity Read ↗

Herpes simplex virus virion host shutoff attenuates establishment of the antiviral state.Semantic proximity Read ↗

Pathogenesis of herpes simplex virus type 2 virion host shutoff (vhs) mutants.Semantic proximity Read ↗

Herpes Simplex Virus Virion Host Shutoff Protein: Immune Evasion Mediated by a Viral RNase?Semantic proximity Read ↗

The virion host shut-off (vhs) protein blocks a TLR-independent pathway of herpes simplex virus type 1 recognition in human and mouse dendritic cells.Semantic proximity Read ↗

Herpes simplex virus virion host shutoff (vhs) activity alters periocular disease in mice.Semantic proximity Read ↗

Functional Genomics Reveals an Essential and Specific Role for Stat1 in Protection of the Central Nervous System following Herpes Simplex Virus Corneal InfectionSemantic proximity Read ↗

The role of the UL41 gene of herpes simplex virus type 1 in evasion of non-specific host defence mechanisms during primary infectionSemantic proximity Read ↗

The herpes simplex virus host shutoff (vhs) RNase limits accumulation of double stranded RNA in infected cells: Evidence for accelerated decay of duplex RNASemantic proximity Read ↗

Role of the virion host shutoff (vhs) of herpes simplex virus type 1 in latency and pathogenesisSemantic proximity Read ↗

Mutational analysis of the virion host shutoff gene (UL41) of herpes simplex virus (HSV): characterization of HSV type 1 (HSV-1)/HSV-2 chimeras.Semantic proximity Read ↗

Isolation of a herpes simplex virus type 1 mutant with a deletion in the virion host shutoff gene and identification of multiple forms of the vhs (UL41) polypeptide.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.