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Article

Rotational movement during cyclic nucleotide-gated channel opening.

Nature - 30 Aug 2001

Johnson J P, Zagotta W N

Abstract excerpt

Cyclic nucleotide-gated (CNG) channels are crucial components of visual, olfactory and gustatory signalling pathways. They open in response to direct binding of intracellular cyclic nucleotides and thus contribute to cellular control of both the membrane potential and intracellular Ca2+ levels. Cytosolic Ni2+ potentiates the rod channel (CNG1) response to cyclic nucleotides and inhibits the olfactory channel...

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PMID: 11528481
DOI: 10.1038/35091089

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