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Article

Structural basis for gating pore current in periodic paralysis.

Nature - 1 May 2018

Jiang Daohua, Gamal El-Din Tamer M, Ing Christopher, Lu Peilong, Pomès Régis, Zheng Ning, Catterall William A

Abstract excerpt

Potassium-sensitive hypokalaemic and normokalaemic periodic paralysis are inherited skeletal muscle diseases characterized by episodes of flaccid muscle weakness1,2. They are caused by single mutations in positively charged residues ('gating charges') in the S4 transmembrane segment of the voltage sensor of the voltage-gated sodium channel Nav1.4 or the calcium channel Cav1.11,2. Mutations of the outermost gating...

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Identifiers

PMID: 29769724
DOI: 10.1038/s41586-018-0120-4
PMCID: PMC6708612

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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