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Article

KLF2-dependent, Shear Stress-induced Expression of CD59

25 Mar 2008

Abstract excerpt

Complement activation may predispose to vascular injury and atherogenesis. The atheroprotective actions of unidirectional laminar shear stress led us to explore its influence on endothelial cell expression of complement inhibitory proteins CD59 and decay-accelerating factor. Human umbilical vein and aortic endothelial cells were exposed to laminar shear stress (12 dynes/cm(2)) or disturbed flow (+/- 5 dynes/cm(2)...

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PMID: 18362151
DOI: 10.1074/jbc.m800362200

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