Article
Anti-tumor activity of ESX1 on cancer cells harboring oncogenic K-ras mutation.
Biochemical and biophysical research communications - 23 May 2008
Nakajima Junta, Ishikawa Susumu, Hamada Jun-Ichi, Yanagihara Masatomo, Koike Takao, Hatakeyama Masanori
Abstract excerpt
Human ESX1 is a 65-kilodalton (kDa) paired-like homeoprotein that is proteolytically processed into N-terminal 45-kDa and C-terminal 20-kDa fragments. The N-terminal ESX1 fragment, which contains the homeodomain, localizes to the nucleus and represses mRNA transcription from the K-ras gene. When we inoculated human colorectal carcinoma HCT116 constitutive expressing N-terminal region of ESX1 (N-ESX1) into nude...
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