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Article

DEAD box protein DDX 1 promotes colorectal tumorigenesis through transcriptional activation of the LGR5 gene

5 Jun 2018

Abstract excerpt

DDX1, a member of the DEAD box RNA helicase family, plays a critical role in testicular tumors. However, it remains to be clarified whether DDX1 is involved in other types of malignant tumors such as colorectal cancer. We disrupted the DDX1 gene in a human colorectal cancer cell line LoVo using the CRISPR/Cas9-mediated gene-targeting system. DDX1-KO LoVo cells exhibited a much slower growth rate, produced fewer...

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PMID: 29869821
DOI: 10.1111/cas.13661

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