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Article

ESX induces transformation and functional epithelial to mesenchymal transition in MCF-12A mammary epithelial cells.

Oncogene - 4 Mar 2004

Schedin Pepper J, Eckel-Mahan Kristin L, McDaniel Shauntae M, Prescott Jason D, Brodsky Kelley S, Tentler John J, Gutierrez-Hartmann Arthur

Abstract excerpt

ESX is an epithelial-restricted member of a large family of transcription factors known as the Ets family. ESX expression has been shown to be correlated with Her2/neu proto-oncogene amplification in highly aggressive breast cancers and induced by Her2/neu in breast cell lines, but its role in tumorigenesis is unknown. Previously, we have shown that ESX enhances breast cell survival in colony-formation assays. In...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14767472
DOI: 10.1038/sj.onc.1207391

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

ESX induces transformation and functional epithelial to mesenchymal transition in MCF-12A mammary epithelial cells.PMID 14767472Read ↗

The epithelial-specific ETS transcription factor ESX/ESE-1/Elf-3 modulates breast cancer-associated gene expression.Semantic proximity Read ↗

Epithelial to mesenchymal transition in human breast epithelial cells transformed by 17beta-estradiol.Semantic proximity Read ↗

Elevated expression of Ets2 or distinct portions of Ets2 can reverse Ras-mediated cellular transformation.Semantic proximity Read ↗

The ETS Transcription Factor ESE-1 Transforms MCF-12A Human Mammary Epithelial Cells via a Novel Cytoplasmic MechanismSemantic proximity Read ↗

Altered Phenotypes of Breast Epithelial × Breast Cancer Hybrids after ZEB1 Knock-Out.Semantic proximity Read ↗

Inhibition of SHP2 leads to mesenchymal to epithelial transition in breast cancer cells.Semantic proximity Read ↗

HER2 induced EMT and tumorigenicity in breast epithelial progenitor cells is inhibited by coexpression of EGFR.Semantic proximity Read ↗

Changes in the Expression of Many Ets Family Transcription Factors and of Potential Target Genes in Normal Mammary Tissue and TumorsSemantic proximity Read ↗

Loss of Function of E-Cadherin in Embryonic Stem Cells and the Relevance to Models of TumorigenesisSemantic proximity Read ↗

Ets-1 expression promotes epithelial cell transformation by inducing migration, invasion and anchorage-independent growth.Semantic proximity Read ↗

Decreased tumorigenicity of c-Myc-transformed fibroblasts expressing active USF2.Semantic proximity Read ↗

Epithelial mesenchymal transition during the neoplastic transformation of human breast epithelial cells by estrogenSemantic proximity Read ↗

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