Cancer/Testis Antigen Expression in Human Mesenchymal Stem Cells: Down-regulation of <i>SSX</i> Impairs Cell Migration and Matrix Metalloproteinase 2 Expression

Abstract excerpt

Several families of genes by and large located on the X chromosome encode proteins of unspecified function. Commonly known as cancer/testis (CT) antigens, they are considered, under normal conditions, only to be expressed in cells of the germ line and placenta. CT genes are also often expressed in cancer cells, hence their classification. Here we report that their expression in normal cells is wider spread and...

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