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Article

Genetic disruption of<i>USP9X</i>sensitizes colorectal cancer cells to 5-fluorouracil

16 Aug 2012

Abstract excerpt

The X-linked deubiquitinase USP9X affects the stability and activity of numerous regulatory proteins that influence cell survival. Recent studies suggest that decreased USP9X expression can confer a selective advantage onto developing cancer cells and thereby promotes disease progression. To examine the effect of USP9X on the cellular responses to anticancer therapies, we derived cancer cell lines in which the...

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PMID: 22895071
DOI: 10.4161/cbt.21792

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