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Article

The epithelial-specific ETS transcription factor ESX/ESE-1/Elf-3 modulates breast cancer-associated gene expression.

DNA and cell biology - 1 Feb 2003

Eckel Kristin L, Tentler John J, Cappetta Gerald J, Diamond Scott E, Gutierrez-Hartmann Arthur

Abstract excerpt

Several members of the ETS family of transcription factors contribute to tumorigenesis in many different tissues, including breast epithelium. The ESX gene is an epithelial-specific Ets member that is particularly relevant to breast cancer. ESX is amplified in early breast cancers, it is overexpressed in human breast ductal carcinoma in situ, and there may be a positive feedback loop between the HER2/neu...

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Source

Identifiers

PMID: 12713734
DOI: 10.1089/104454903321515896

Genes

CAT
EHF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The epithelial-specific ETS transcription factor ESX/ESE-1/Elf-3 modulates breast cancer-associated gene expression.PMID 12713734Read ↗

ESX induces transformation and functional epithelial to mesenchymal transition in MCF-12A mammary epithelial cells.Semantic proximity Read ↗

ESX: a structurally unique Ets overexpressed early during human breast tumorigenesisSemantic proximity Read ↗

Changes in the Expression of Many Ets Family Transcription Factors and of Potential Target Genes in Normal Mammary Tissue and TumorsSemantic proximity Read ↗

The transcription factor Ets-1 in breast cancer.Semantic proximity Read ↗

The ETS Transcription Factor ESE-1 Transforms MCF-12A Human Mammary Epithelial Cells via a Novel Cytoplasmic MechanismSemantic proximity Read ↗

The Epithelium-specific ETS Protein EHF/ESE-3 Is a Context-dependent Transcriptional Repressor Downstream of MAPK Signaling CascadesSemantic proximity Read ↗

Anti-tumor activity of ESX1 on cancer cells harboring oncogenic K-ras mutation.Semantic proximity Read ↗

Constitutive and Cytokine-Induced Expression of the ETS Transcription Factor ESE-3 in the LungSemantic proximity Read ↗

Ets-1 expression promotes epithelial cell transformation by inducing migration, invasion and anchorage-independent growth.Semantic proximity Read ↗

ESE‐1 inhibits the invasion of oral squamous cell carcinoma in conjunction with MMP‐9 suppressionSemantic proximity Read ↗

Differentiation-specific transcriptional regulation of the ESE-2 gene by a novel keratinocyte-restricted factor.Semantic proximity Read ↗

A single ets-related transcription factor, E1AF, confers invasive phenotype on human cancer cells.Semantic proximity Read ↗

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