Article
The function of GPI-anchored proteins in T cell development, activation and regulation of homeostasis.
Journal of biological regulators and homeostatic agents - 1 Jan 2000
Marmor M D, Julius M
Abstract excerpt
Many glycosylphosphatidyl-inositol-anchored proteins (GPI-AP) are expressed on T lymphocytes. Ligand or mAb-mediated aggregation of all GPI-AP tested to date results in the initiation of signal transduction pathways via the activation of src family protein tyrosine kinases. Src family kinases co-localise with GPI-AP in specialised sub-domains of the plasma membrane, referred to as detergent insoluble membrane...
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