Article
A phosphatidylinositol-linkage-deficient T-cell mutant contains insulin-sensitive glycosyl-phosphatidylinositol.
The Biochemical journal - 15 Mar 1992
Avila M A, Clemente R, Varela-Nieto I
Abstract excerpt
Glycosyl-phosphatidylinositol molecules, acting as both signal transduction elements and membrane protein anchors, have been proposed to play a role during T-cell activation. The MVB2 cell line is a mutant, derived from the wild-type T-T hybrid YH.16.33, which has a defect in the biosynthesis of...
Topics
- Animals
- Cell Membrane
- Glucosamine
- Glycolipids
- Glycosylphosphatidylinositols
- Hydrolysis
- Inositol Phosphates
- Insulin
- Iodine Radioisotopes
- Lipid Metabolism
- Lymphocyte Activation
- Mice
- Mutation
- Phosphatidylinositols
- Polysaccharides
- Signal Transduction
- T-Lymphocytes
- Tritium