Article
Functional competence of T cells in the absence of glycosylphosphatidylinositol-anchored proteins caused by T cell-specific disruption of the Pig-a gene.
European journal of immunology - 1 Jul 1998
Takahama Y, Ohishi K, Tokoro Y, Sugawara T, Yoshimura Y, Okabe M, Kinoshita T, Takeda J
Abstract excerpt
T lymphocytes express various glycosylphosphatidylinositol (GPI)-anchored surface proteins, such as Thy-1 and Ly-6A. However, functional contribution of GPI-anchored proteins in T cell activation is as yet poorly understood. Here we report the generation of mutant mice deficient in the expression...
Topics
- Alleles
- Animals
- Glycosylphosphatidylinositols
- Lymphocyte Activation
- Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
- Membrane Proteins
- Mice
- Promoter Regions, Genetic
- Receptors, Antigen, T-Cell
- T-Lymphocytes