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Article

DNA separation methodology based on charge neutralization in a polycationic gel matrix.

Analytical chemistry - 1 Jul 2008

Zilberstein Gleb, Korol Leonid, Znaleziona Joanna, Sebastiano Roberto, Righetti Pier Giorgio, Shlar Ilya, Baskin Emmanuil, Bukshpan Shmuel

Abstract excerpt

A novel method for separation of DNA fragments is here reported, based on migrating the polyanionic DNA fragments in a polycationic polyacrylamide gel, made by incorporating positively charged monomers (the Immobilines used for creating immobilized pH gradients) into the neutral polyacrylamide backbone. Separations can be operated under two working conditions: either against a gradient of positive charges, to...

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PMID: 18355088
DOI: 10.1021/ac800095e

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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